Nespelem is a town in Okanogan County, Washington, United States. The population was 236 at the 2010 census. The town is located on the Colville Indian Reservation. The name Nespelem is derived from a local Indian term meaning "large flat meadow".
Nespelem was officially incorporated on April 15, 1935. Nespelem is the site of an historic Nez Perce cemetery. Among those buried there is Chief Joseph.